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Article

Structure of the heterodimeric complex between CAD domains of CAD and ICAD.

Nature structural biology - 1 Aug 2000

Otomo T, Sakahira H, Uegaki K, Nagata S, Yamazaki T

Abstract excerpt

We present here the structure of the complex between the CAD domain of caspase activated deoxyribonuclease (CAD) and the CAD domain of its inhibitor (ICAD), determined by nuclear magnetic resonance spectroscopy. The two domains adopt a very similar fold, which consists of an alpha-helix and a beta-sheet, and are aligned side by side in the complex. Notably, the positive charges on the strand beta2 at one end of...

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Source

Identifiers

PMID: 10932250
DOI: 10.1038/77957

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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