Article
Association of genetic variants in the Rho guanine nucleotide exchange factor AKAP13 with familial breast cancer.
Carcinogenesis - 1 Mar 2006
Wirtenberger Michael, Tchatchou Sandrine, Hemminki Kari, Klaes Rüdiger, Schmutzler Rita K, Bermejo Justo L, Chen Bowang, Wappenschmidt Barbara, Meindl Alfons, Bartram Claus R, Burwinkel Barbara
Abstract excerpt
The A-kinase anchor protein 13 (AKAP13, alias BRX and lbc) tethers cAMP-dependent protein kinase to its subcellular environment and catalyses Rho GTPases activity as a guanine nucleotide exchange factor. The crucial role of members of the Rho family of GTPases in carcinogenesis is well established and targeting Rho proteins with antineoplastic compounds has become a major effort in the fight against cancer. Thus,...
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