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Oncogenic mechanisms of HOXB13 missense mutations in prostate carcinogenesis

31 Oct 2016

Abstract excerpt

The recurrent germline mutation HOXB13 p.(Gly84Glu) (G84E) has recently been identified as a risk factor for prostate cancer. In a recent study, we have performed full sequencing of the HOXB13 gene in 462 Portuguese prostate cancer patients with early-onset and/or familial/hereditary disease, and identified two novel missense mutations, p.(Ala128Asp) (A128D) and p.(Phe240Leu) (F240L), that were predicted to be...

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PMID: 28050579
DOI: 10.18632/oncoscience.322

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