Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotype frequencies in a sub-region of chromosome 19q13.3, related to risk and prognosis of cancer, differ dramatically between ethnic groups.

BMC medical genetics - 3 Mar 2009

Schierup Mikkel H, Mailund Thomas, Li Heng, Wang Jun, Tjønneland Anne, Vogel Ulla, Bolund Lars, Nexø Bjørn A

Abstract excerpt

BACKGROUND: A small region of about 70 kb on human chromosome 19q13.3 encompasses 4 genes of which 3, ERCC1, ERCC2, and PPP1R13L (aka RAI) are related to DNA repair and cell survival, and one, CD3EAP, aka ASE1, may be related to cell proliferation. The whole region seems related to the cellular response to external damaging agents and markers in it are associated with risk of several cancers. METHODS: We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Black People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Chromosomes, Human, Pair 19

Share to Genetic Markers

Share to Molecular Epidemiology

Share to Neoplasms

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 19257887
DOI: 10.1186/1471-2350-10-20
PMCID: PMC2654437

Genes

ERCC1
ERCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotype frequencies in a sub-region of chromosome 19q13.3, related to risk and prognosis of cancer, differ dramatically between ethnic groups.PMID 19257887Read ↗

HapMap-based study identifies risk sub-region on chromosome 19q13.3 in relation to lung cancer among Chinese.Semantic proximity Read ↗

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.Semantic proximity Read ↗

ATP2A3 gene is involved in cancer susceptibility.Semantic proximity Read ↗

Two novel variants on 13q22.1 are associated with risk of esophageal squamous cell carcinoma.Semantic proximity Read ↗

Multiple single nucleotide polymorphisms on human chromosome 19q13.2-3 associate with risk of Basal cell carcinoma.Semantic proximity Read ↗

Common variants at 19p13 are associated with susceptibility to ovarian cancer.Semantic proximity Read ↗

A regulatory variant at 19p13.3 is associated with primary biliary cholangitis risk and ARID3A expression.Semantic proximity Read ↗

A specific haplotype of single nucleotide polymorphisms on chromosome 19q13.2-3 encompassing the gene RAI is indicative of post-menopausal breast cancer before age 55.Semantic proximity Read ↗

Hapmap-based evaluation of ERCC2, PPP1R13L, and ERCC1 and lung cancer risk in a Chinese population.Semantic proximity Read ↗

Haplotype patterns in cancer-related genes with long-range linkage disequilibrium: no evidence of association with breast cancer or positive selection.Semantic proximity Read ↗

A functional variant at 19q13.3, rs967591G>A, is associated with shorter survival of early-stage lung cancer.Semantic proximity Read ↗

Association of chromosome 19q13.2-3 haplotypes with basal cell carcinoma: tentative delineation of an involved region using data for single nucleotide polymorphisms in two cohorts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.