Article
The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer.
Carcinogenesis - 1 Feb 2007
Wirtenberger Michael, Schmutzhard Julia, Hemminki Kari, Meindl Alfons, Sutter Christian, Schmutzler Rita K, Wappenschmidt Barbara, Kiechle Marion, Arnold Norbert, Weber Bernhard H F, Niederacher Dieter, Bartram Claus R, Burwinkel Barbara
Abstract excerpt
Overexpression of cAMP-dependent protein kinase A (PKA) is a hallmark of the great majority of human cancers including breast cancer. A-kinase anchoring proteins (AKAPs) coordinate the specificity of PKA signalling by localizing the kinase to its subcellular sites. We tested the hypothesis whethe...
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