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Article

Recurrent HOXB13 mutations in the Dutch population do not associate with increased breast cancer risk.

Scientific reports - 18 Jul 2016

Liu Jingjing, Prager-van der Smissen Wendy J C, Schmidt Marjanka K, Collée J Margriet, Cornelissen Sten, Lamping Roy, Nieuwlaat Anja, Foekens John A, Hooning Maartje J, Verhoef Senno, van den Ouweland Ans M W, Hogervorst Frans B L, Martens John W M, Hollestelle Antoinette

Abstract excerpt

The HOXB13 p.G84E mutation has been firmly established as a prostate cancer susceptibility allele. Although HOXB13 also plays a role in breast tumor progression, the association of HOXB13 p.G84E with breast cancer risk is less evident. Therefore, we comprehensively interrogated the entire HOXB13 coding sequence for mutations in 1,250 non-BRCA1/2 familial breast cancer cases and 800 controls. We identified two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27424772
DOI: 10.1038/srep30026
PMCID: PMC4948019

Genes

HOXB13
BRCA1

Variants

Provenance

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Recurrent HOXB13 mutations in the Dutch population do not associate with increased breast cancer risk.PMID 27424772Read ↗

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G84E mutation in HOXB13 is firmly associated with prostate cancer risk: a meta-analysis.Semantic proximity Read ↗

The HOXB13 p.Gly84Glu mutation is not associated with the risk of breast cancer.Semantic proximity Read ↗

Prevalence of the HOXB13 G84E germline mutation in British men and correlation with prostate cancer risk, tumour characteristics and clinical outcomes.Semantic proximity Read ↗

HOXB13, a high-risk prostate cancer gene, also confers risk for breast cancer: novel variants of clinical significance, especially in hormone-positive patients.Semantic proximity Read ↗

Prevalence of the HOXB13 G84E mutation in Danish men undergoing radical prostatectomy and its correlations with prostate cancer risk and aggressiveness.Semantic proximity Read ↗

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