Article
Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer.
Carcinogenesis - 1 Nov 2006
Wirtenberger Michael, Tchatchou Sandrine, Hemminki Kari, Schmutzhard Julia, Sutter Christian, Schmutzler Rita K, Meindl Alfons, Wappenschmidt Barbara, Kiechle Marion, Arnold Norbert, Weber Bernhard H F, Niederacher Dieter, Bartram Claus R, Burwinkel Barbara
Abstract excerpt
The mitogen effect of the ovarian steroid estrogen is a strong risk factor for breast cancer development. This effect is mainly mediated by the estrogen receptor alpha, a hormone inducible transcription factor, which activates gene expression through recruiting multiple coactivators, such as PPARGC1A, PPARGC1B and EP300. We tested the hypothesis that non-conservative, putative functional amino acid exchanges in...
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