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Article

Rho GTPase gene expression and breast cancer risk: a Mendelian randomization analysis.

Scientific reports - 27 Jan 2022

Kazmi Nabila, Robinson Tim, Zheng Jie, Kar Siddhartha, Martin Richard M, Ridley Anne J

Abstract excerpt

The Rho GTPase family consists of 20 genes encoding intracellular signalling proteins that influence cytoskeletal dynamics, cell migration and cell cycle progression. They are implicated in breast cancer progression but their role in breast cancer aetiology is unknown. As aberrant Rho GTPase activity could be associated with breast cancer, we aimed to determine the potential for a causal role of Rho GTPase gene...

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Identifiers

PMID: 35087170
DOI: 10.1038/s41598-022-05549-5
PMCID: PMC8795400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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