Article
Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis.
Journal of the National Cancer Institute - 19 Mar 2008
Frank Bernd, Wiestler Miriam, Kropp Silke, Hemminki Kari, Spurdle Amanda B, Sutter Christian, Wappenschmidt Barbara, Chen Xiaoqing, Beesley Jonathan, Hopper John L, Meindl Alfons, Kiechle Marion, Slanger Tracy, Bugert Peter, Schmutzler Rita K, Bartram Claus R, Flesch-Janys Dieter, Mutschelknauss Elke, Ashton Katie, Salazar Ramona, Webb Emily, Hamann Ute, Brauch Hiltrud, Justenhoven Christina, Ko Yon-Dschun, Brüning Thomas, Silva Isabel dos Santos, Johnson Nichola, Pharoah Paul P D, Dunning Alison M, Pooley Karen A, Chang-Claude Jenny, Easton Douglas F, Peto Julian, Houlston Richard, Chenevix-Trench Georgia, Fletcher Olivia, Burwinkel Barbara
Abstract excerpt
Data from several studies have suggested that polymorphisms in A-kinase anchoring proteins (AKAPs), which are key components of signal transduction, contribute to carcinogenesis. To evaluate the impact of AKAP variants on breast cancer risk, we genotyped six nonsynonymous single-nucleotide polymorphisms that were predicted to be deleterious and found two (M463I, 1389G>T and N2792S, 8375A>G) to be associated with...
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