Article
ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers.
Gene - 7 Jul 2004
Johnstone Cameron N, Castellví-Bel Sergi, Chang Laura M, Bessa Xavier, Nakagawa Hiroshi, Harada Hideki, Sung Raphael K, Piqué Josep M, Castells Antoni, Rustgi Anil K
Abstract excerpt
The RHO family of small GTPases has multiple functions, including regulation of cytoskeletal organization, cell cycle progression and cell migration, among others. The key members of this family are RHO, RAC and CDC42. Active GTP-bound RHO proteins are down-regulated by RHO GTPase-activating proteins (RHOGAPs). Herein, we describe the identification, characterization and mutational analysis of a novel RHOGAP...
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