Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor-derived ARHGAP35 mutations enhance the Gα13-Rho signaling axis in human endometrial cancer.

Cancer gene therapy - 1 Feb 2023

Yagi Hiroshi, Onoyama Ichiro, Asanoma Kazuo, Kawakami Minoru, Maenohara Shoji, Kodama Keisuke, Matsumura Yumiko, Hamada Norio, Hori Emiko, Hachisuga Kazuhisa, Yasunaga Masafumi, Ohgami Tatsuhiro, Okugawa Kaoru, Yahata Hideaki, Kato Kiyoko

Abstract excerpt

Dysregulated G protein-coupled receptor signaling is involved in the formation and progression of human cancers. The heterotrimeric G protein Gα13 is highly expressed in various cancers and regulates diverse cancer-related transcriptional networks and cellular functions by activating Rho. Herein, we demonstrate that increased expression of Gα13 promotes cell proliferation through activation of Rho and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Endometrial Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Mutation

Share to Protein Kinase Regulation and GTPase Signaling

Share to Receptor Mechanisms and Signaling

Share to Repressor Proteins

Share to Signal Transduction

Source

Identifiers

PMID: 36257976
DOI: 10.1038/s41417-022-00547-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor-derived ARHGAP35 mutations enhance the Gα13-Rho signaling axis in human endometrial cancer.PMID 36257976Read ↗

ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers.Semantic proximity Read ↗

p190A/ <i>ARHGAP35</i> and p190B/ <i>ARHGAP5</i> proteins in endometrial cancer, a novel cancer-relevant paralog interplaySemantic proximity Read ↗

Comprehensive analysis on the whole Rho‐GAP family reveals that ARHGAP4 suppresses EMT in epithelial cells under negative regulation by Septin9Semantic proximity Read ↗

Fixing the GAP: The role of RhoGAPs in cancerSemantic proximity Read ↗

Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.Semantic proximity Read ↗

Mutant p53 promotes cell spreading and migration via ARHGAP44.Semantic proximity Read ↗

Variegated RHOA mutations in human cancers.Semantic proximity Read ↗

Regulator of G-protein signaling (RGS) proteins in cancer biology.Semantic proximity Read ↗

Rho GTPase activating proteins in cancer phenotypes.Semantic proximity Read ↗

Identification and characterization of ARHGAP27 gene in silicoSemantic proximity Read ↗

The emerging roles of GPRC5A in diseasesSemantic proximity Read ↗

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.