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Article

Functional characterization of 2',5'-linked oligoadenylate binding determinant of human RNase L.

The Journal of biological chemistry - 16 Dec 2005

Nakanishi Masayuki, Tanaka Nobutada, Mizutani Yasuaki, Mochizuki Masahiko, Ueno Yoshihito, Nakamura Kazuo T, Kitade Yukio

Abstract excerpt

RNase L is activated by the binding of unusual 2',5'-linked oligoadenylates (2-5A) and acts as the effector enzyme of the 2-5A system, an interferon-induced anti-virus mechanism. Efforts have been made to understand the 2-5A binding mechanism, not only for scientific interests but also for the prospects that the understanding of such mechanisms lead to new remedies for viral diseases. We have recently elucidated...

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PMID: 16234235
DOI: 10.1074/jbc.M507424200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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