Article
Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation.
Nucleic acids research - 7 May 2021
Abula Abudureyimu, Li Xiaona, Quan Xing, Yang Tingting, Liu Yue, Guo Hangtian, Li Tinghan, Ji Xiaoyun
Abstract excerpt
RNA 2'-O-methylation is widely distributed and plays important roles in various cellular processes. Mycoplasma genitalium RNase R (MgR), a prokaryotic member of the RNase II/RNB family, is a 3'-5' exoribonuclease and is particularly sensitive to RNA 2'-O-methylation. However, how RNase R interacts with various RNA species and exhibits remarkable sensitivity to substrate 2'-O-methyl modifications remains elusive....
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