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Article

N6-Allyladenosine: A New Small Molecule for RNA Labeling Identified by Mutation Assay.

Journal of the American Chemical Society - 6 Dec 2017

Shu Xiao, Dai Qing, Wu Tong, Bothwell Ian R, Yue Yanan, Zhang Zezhou, Cao Jie, Fei Qili, Luo Minkui, He Chuan, Liu Jianzhao

Abstract excerpt

RNA labeling is crucial for the study of RNA structure and metabolism. Herein we report N6-allyladenosine (a6A) as a new small molecule for RNA labeling through both metabolic and enzyme-assisted manners. a6A behaves like A and can be metabolically incorporated into newly synthesized RNAs inside mammalian cells. We also show that human RNA N6-methyladenosine (m6A) methyltransferases METTL3/METTL14 can work with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29116772
DOI: 10.1021/jacs.7b06837
PMCID: PMC5813804

Genes

METTL14
METTL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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