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Article

A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L.

RNA (New York, N.Y.) - 1 Jun 2008

Townsend Hannah L, Jha Babal K, Han Jian-Qiu, Maluf N Karl, Silverman Robert H, Barton David J

Abstract excerpt

Ribonuclease L (RNase L) is a latent endoribonuclease in an evolutionarily ancient interferon-regulated dsRNA-activated antiviral pathway. 2'-5' oligoadenylate (2-5A), the product of dsRNA-activated oligoadenylate synthetases (OASes), binds to ankyrin repeats near the amino terminus of RNase L, initiating a series of conformational changes that result in the activation of the endoribonuclease. A phylogenetically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18426919
DOI: 10.1261/rna.958908
PMCID: PMC2390801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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