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Article

The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition.

Nucleic acids research - 1 Aug 2008

Nagata Takashi, Suzuki Sakura, Endo Ryuta, Shirouzu Mikako, Terada Takaho, Inoue Makoto, Kigawa Takanori, Kobayashi Naohiro, Güntert Peter, Tanaka Akiko, Hayashizaki Yoshihide, Muto Yutaka, Yokoyama Shigeyuki

Abstract excerpt

The degradation of the poly(A) tail is crucial for posttranscriptional gene regulation and for quality control of mRNA. Poly(A)-specific ribonuclease (PARN) is one of the major mammalian 3' specific exo-ribonucleases involved in the degradation of the mRNA poly(A) tail, and it is also involved in the regulation of translation in early embryonic development. The interaction between PARN and the m(7)GpppG cap of...

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Identifiers

PMID: 18641416
DOI: 10.1093/nar/gkn458
PMCID: PMC2504292

Genes

PARN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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