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Article

Structural architecture of an RNA that competitively inhibits RNase L.

RNA (New York, N.Y.) - 1 Jan 2012

Keel Amanda Y, Jha Babal Kant, Kieft Jeffrey S

Abstract excerpt

Activation of RNase L endonuclease activity is part of the mammalian innate immune response to viral infection. The poliovirus RNA genome contains a sequence in its protein-coding region that can act as a competitive inhibitor of RNase L. Mutation, sequence, and functional analysis of this competitive inhibitor RNA (ciRNA) revealed that its activity depends on specific sequences, showed that a loop-loop hairpin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22114318
DOI: 10.1261/rna.030007.111
PMCID: PMC3261747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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