Article
A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.
Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2005
Malathi Krishnamurthy, Paranjape Jayashree M, Bulanova Elena, Shim Minsub, Guenther-Johnson Jeanna M, Faber Pieter W, Eling Thomas E, Williams Bryan R G, Silverman Robert H
Abstract excerpt
Virus replication in higher vertebrates is restrained by IFNs that cause cells to transcribe genes encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases. 2'-5' oligoadenylate synthetase is stimulated by dsRNA to produce 5'-phosphorylated, 2'-5'-linked oligoadenylates (2-5A), whose function is to activate RNase L. Although RNase L is required for a complete IFN antiviral response and mutations in...
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