Stable expression of a cDNA encoding rat brain protein kinase C-beta I confers a multidrug-resistant phenotype on rat fibroblasts.

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Article

Stable expression of a cDNA encoding rat brain protein kinase C-beta I confers a multidrug-resistant phenotype on rat fibroblasts.

Anticancer research - 1 Jan 2000

Fan D, Fidler I J, Ward N E, Seid C, Earnest L E, Housey G M, O'Brian C A

Abstract excerpt

Protein kinase C (PKC) is a Ca++- and phospholipid-dependent protein kinase that plays an important role in signal transduction pathways that regulate cell growth. Tumor cells selected for a multidrug resistant (MDR) phenotype often express elevated levels of PKC activity. To directly test whether PCK overexpression can produce an MDR phenotype, we studied rat embryo fibroblasts that were infected with the...

Topics

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
Animals
Brain
Cell Line
Cloning, Molecular
DNA
Dactinomycin
Doxorubicin
Drug Resistance
Fibroblasts
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoenzymes

Isoquinolines

Kinetics

Phenotype

Piperazines

Protein Kinase C

Protein Kinase Inhibitors

Source

Open in PubMed

Identifiers

PMID: 1622123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1622123-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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