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Article

Failure of wild-type or a mutant form of protein kinase C-alpha to transform fibroblasts.

Nature - 5 Sept 1991

Borner C, Filipuzzi I, Weinstein I B, Imber R

Abstract excerpt

A mutant form of the alpha-isoform of protein kinase C (PKC) was recently isolated from an ultraviolet radiation-induced murine fibrosarcoma cell line and reported to transform mouse BALB/c 3T3 fibroblasts on transfection. Four point mutations in the regulatory domain were assumed to be responsible for its oncogenicity and unusual preference for membrane localization. Here, we report that overexpression of the...

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PMID: 1881450
DOI: 10.1038/353078a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Failure of wild-type or a mutant form of protein kinase C-alpha to transform fibroblasts.PMID 1881450Read ↗

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Alterations in cellular phenotype induced by the type 5 adenovirus E1A and the beta 1 protein kinase C genes in cloned rat embryo fibroblast cells.Semantic proximity Read ↗

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Expression of platelet-derived growth factor-independent phenotypes in BALB/c 3T3 cell variant with high susceptibility to chemically or physically induced neoplastic cell transformation: dissociation from activation of protein kinase C.Semantic proximity Read ↗

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