Article
Failure of wild-type or a mutant form of protein kinase C-alpha to transform fibroblasts.
Nature - 5 Sept 1991
Borner C, Filipuzzi I, Weinstein I B, Imber R
Abstract excerpt
A mutant form of the alpha-isoform of protein kinase C (PKC) was recently isolated from an ultraviolet radiation-induced murine fibrosarcoma cell line and reported to transform mouse BALB/c 3T3 fibroblasts on transfection. Four point mutations in the regulatory domain were assumed to be responsib...
Topics
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- DNA
- Fibroblasts
- Fibrosarcoma
- Gene Expression
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Mutation
- Protein Kinase C
- Rats
- Tetradecanoylphorbol Acetate
- Transfection