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Article

Transient enhancement of multidrug resistance by the bile acid deoxycholate in murine fibrosarcoma cells in vitro.

Biochemical pharmacology - 1 Mar 1991

O'Brian C A, Fan D, Ward N E, Dong Z, Iwamoto L, Gupta K P, Earnest L E, Fidler I J

Abstract excerpt

Recent studies have implicated protein kinase C (PKC) activation in drug resistance in vitro. PKC can be activated directly by phorbol-ester tumor promoters as well as by the bile acid deoxycholate. In this report, we demonstrate that deoxycholate, at concentrations that are chronically present in the lumen of the colon in vivo, mimicked phorbol-ester tumor promoters by protecting Adriamycin (ADR)-sensitive and...

Topics

Animals
Cell Division
Dactinomycin
Deoxycholic Acid
Doxorubicin
Drug Resistance
Fibrosarcoma
Intestinal Neoplasms
Isoenzymes
Mice
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phorbol Esters

Protein Kinase C

Tumor Cells, Cultured

Vinblastine

Vincristine

Source

Identifiers

PMID: 1998534
DOI: 10.1016/0006-2952(91)90083-h

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1998534-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Transient enhancement of multidrug resistance by the bile acid deoxycholate in murine fibrosarcoma cells in vitro.PMID 1998534Read ↗

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