Article
Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.
The Journal of biological chemistry - 5 Jan 1993
Blobe G C, Sachs C W, Khan W A, Fabbro D, Stabel S, Wetsel W C, Obeid L M, Fine R L, Hannun Y A
Abstract excerpt
The multidrug resistance (MDR) phenotype induces cross-resistance to many chemotherapeutic agents in cancer cells. Protein kinase C (PKC) has been implicated in the regulation of the MDR phenotype. In order to determine the role of specific PKC isoenzymes in regulating the MDR phenotype, the expr...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Blotting, Northern
- Blotting, Western
- Breast Neoplasms
- Calcium
- Chromatography
- Doxorubicin
- Drug Resistance
- Durapatite
- Female
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Humans