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Article

Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2.

Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2005

Leppilampi Mari, Parkkila Seppo, Karttunen Tuomo, Gut Marta Ortova, Gros Gerolf, Sjöblom Markus

Abstract excerpt

Duodenal bicarbonate secretion (DBS) is accepted as the primary mucosal defense against acid discharged from the stomach and is impaired in patients with duodenal ulcer disease. The secretory response to luminal acid is the main physiological stimulus for DBS and involves mediation by PGE2 produced by mucosal cells. The aim of this investigation is to elucidate the role of carbonic anhydrases (CAs) II and IX in...

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Identifiers

PMID: 16217040
DOI: 10.1073/pnas.0508007102
PMCID: PMC1257747

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