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Article

Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon.

The Journal of clinical investigation - 1 May 2010

Yu Kuai, Lujan Rafael, Marmorstein Alan, Gabriel Sherif, Hartzell H Criss

Abstract excerpt

Anion transport by the colonic mucosa maintains the hydration and pH of the colonic lumen, and its disruption causes a variety of diarrheal diseases. Cholinergic agonists raise cytosolic Ca2+ levels and stimulate anion secretion, but the mechanisms underlying this effect remain unclear. Cholinergic stimulation of anion secretion may occur via activation of Ca2+-activated Cl- channels (CaCCs) or an increase in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20407206
DOI: 10.1172/JCI41129
PMCID: PMC2860923

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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