Article
Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach.
BMC genomics - 23 Jun 2010
Kallio Heini, Hilvo Mika, Rodriguez Alejandra, Lappalainen Eeva-Helena, Lappalainen Anna-Maria, Parkkila Seppo
Abstract excerpt
BACKGROUND: Carbonic anhydrases (CAs) are a family of enzymes that regulate pH homeostasis in various tissues. CA IX is an exceptional member of this family because in addition to the basic CA function, it has been implicated in several other physiological and pathological processes. Functions suggested for CA IX include roles in cell adhesion and malignant cell invasion. In addition, CA IX likely regulates cell...
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