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Article

A role for guanylate cyclase C in acid-stimulated duodenal mucosal bicarbonate secretion.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jan 2004

Rao S P, Sellers Z, Crombie D L, Hogan D L, Mann E A, Childs D, Keely S, Sheil-Puopolo M, Giannella R A, Barrett K E, Isenberg J I, Pratha V S

Abstract excerpt

Luminal acidification provides the strongest physiological stimulus for duodenal HCO3- secretion. Various neurohumoral mechanisms are believed to play a role in acid-stimulated HCO3- secretion. Previous studies in the rat and human duodenum have shown that guanylin and Escherichia coli heat-stable toxin, both ligands of the transmembrane guanylyl cyclase receptor [guanylate cyclase C (GC-C)], are potent...

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Source

Identifiers

PMID: 12881226
DOI: 10.1152/ajpgi.00087.2003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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