Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms.

American journal of physiology. Renal physiology - 1 Mar 2008

Lynch I Jeanette, Rudin Alicia, Xia Shen-Ling, Stow Lisa R, Shull Gary E, Weiner I David, Cain Brian D, Wingo Charles S

Abstract excerpt

Two classes of H pumps, H-K-ATPase and H-ATPase, contribute to luminal acidification and HCO(3) transport in the collecting duct (CD). At least two H-K-ATPase alpha-subunits are expressed in the CD: HKalpha(1) and HKalpha(2). Both exhibit K dependence but have different inhibitor sensitivities. The HKalpha(1) H-K-ATPase is Sch-28080 sensitive, whereas the pharmacological profile of the HKalpha(2) H-K-ATPase is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acids
Share to Amiloride

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anti-Arrhythmia Agents

Share to Kidney Tubules, Collecting

Share to Macrolides

Share to Proton-Translocating ATPases

Share to Protons

Source

Identifiers

PMID: 18057185
DOI: 10.1152/ajprenal.00412.2007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms.PMID 18057185Read ↗

ENaC activity in the cortical collecting duct of HKα1 H+,K+-ATPase knockout mice is uncoupled from Na+ intake.Semantic proximity Read ↗

H+,K+-ATPase.Semantic proximity Read ↗

H-K-ATPase type 2: relevance for renal physiology and beyond.Semantic proximity Read ↗

<i>SLC4A1</i> MUTATIONS THAT CAUSE DISTAL RENAL TUBULAR ACIDOSIS ALTER CYTOPLASMIC PH AND CELLULAR AUTOPHAGYSemantic proximity Read ↗

Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis.Semantic proximity Read ↗

Collecting duct intercalated cell function and regulation.Semantic proximity Read ↗

Kidney collecting duct acid-base “regulon”Semantic proximity Read ↗

Urinary Sodium Wasting and Disrupted Collecting Duct Function in Mice with dRTA-Causing <i>SLC4A1</i> MutationsSemantic proximity Read ↗

Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations.Semantic proximity Read ↗

SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy.Semantic proximity Read ↗

Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency.Semantic proximity Read ↗

Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.