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Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids.

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2021

Fujiwara Yuta, Yamane Shunsuke, Harada Norio, Ikeguchi-Ogura Eri, Usui Ryota, Nakamura Toshihiro, Iwasaki Kanako, Suzuki Kazuyo, Yabe Daisuke, Hayashi Yoshitaka, Inagaki Nobuya

Abstract excerpt

Glucagon-like peptide-1 (GLP-1) is an incretin secreted from enteroendocrine preproglucagon (PPG)-expressing cells (traditionally known as L cells) in response to luminal nutrients that potentiates insulin secretion. Augmentation of endogenous GLP-1 secretion might well represent a novel therapeutic target for diabetes treatment in addition to the incretin-associated drugs currently in use. In this study, we...

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PMID: 33533304
DOI: 10.1152/ajpgi.00312.2020

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