Article
Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2007
Rame J Eduardo, Drazner Mark H, Post Wendy, Peshock Ronald, Lima Joao, Cooper Richard S, Dries Daniel L
Abstract excerpt
Corin activates pro-A-type naturetic peptide and pro-B-type naturetic peptide into biologically active molecules. We recently identified a minor allele in the corin gene defined by 2 highly linked single nucleotide polymorphisms (T555I and Q568P), which was associated with hypertension in blacks. Because of the direct antihypertrophic effects of the natriuretic peptide system, we hypothesized that the minor corin...
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