Article
Tumor-associated serpin, squamous cell carcinoma antigen stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines.
International journal of oncology - 1 Nov 2005
Sueoka Kotaro, Nawata Shugo, Nakagawa Tatsushi, Murakami Akihiro, Takeda Osamu, Suminami Yoshinori, Kato Hiroshi, Sugino Norihiro
Abstract excerpt
Squamous cell carcinoma antigen (SCCA) is clinically used as a tumor marker for patients with squamous cell carcinoma of various organs. SCCA1 and its highly homologous molecule, SCCA2, belong to the serine proteinase inhibitors (serpins) family, suggesting that these proteins may be involved in the malignant behavior of squamous cell carcinoma cells. The aim of this study is to functionally characterize these...
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