Article
The p38 SAPK pathway regulates the expression of the MMP-9 collagenase via AP-1-dependent promoter activation.
Experimental cell research - 10 Dec 2001
Simon C, Simon M, Vucelic G, Hicks M J, Plinkert P K, Koitschev A, Zenner H P
Abstract excerpt
The invasive phenotype of cancers critically depends on the expression of proteases such as the M(R) 92,000 type IV collagenase (MMP-9). Several growth factors and oncogenes were found to increase promoter activity and as a consequence protease expression. This frequently requires the activation of the transcription factor AP-1 by signal transduction cascades such as the ERK and JNK pathways. We have previously...
Topics
- Base Sequence
- Calcium-Calmodulin-Dependent Protein Kinases
- Carcinogens
- Enzyme Inhibitors
- Gene Expression Regulation, Neoplastic
- Genes, Reporter
- Humans
- Imidazoles
- MAP Kinase Kinase 6
- Matrix Metalloproteinase 9
- Mitogen-Activated Protein Kinases
- Mutation
- Neoplasm Invasiveness