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Article

Crystal structure of SCCA1 and insight about the interaction with JNK1.

Biochemical and biophysical research communications - 27 Feb 2009

Zheng Bin, Matoba Yasuyuki, Kumagai Takanori, Katagiri Chika, Hibino Toshihiko, Sugiyama Masanori

Abstract excerpt

Squamous cell carcinoma antigen 1 (SCCA1), which belongs to serine proteinase inhibitor (serpin) superfamily, inhibits papain-like cysteine proteinase. Recently, it has been reported that SCCA1 acts not only as a proteinase inhibitor but also as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). The present study determined the crystal structure of SCCA1,...

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Share to Antigens, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19166818
DOI: 10.1016/j.bbrc.2009.01.057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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