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Article

Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma.

Cancer research - 15 May 2008

Mitra Raj S, Goto Mitsuo, Lee Julia S, Maldonado Diana, Taylor Jeremy M G, Pan Quintin, Carey Thomas E, Bradford Carol R, Prince Mark E, Cordell Kitrina G, Kirkwood Keith L, D'Silva Nisha J

Abstract excerpt

The objective of the current study was to investigate the effects of Rap1GAP on invasion and progression of head and neck squamous cell carcinoma (SCC) and the role of matrix metalloproteinase (MMP) 9 and MMP2 in this process. Rap1GAP functions by switching off Rap1, the Ras-like protein that has been associated with carcinogenesis. Previous findings suggest that Rap1GAP acts as a tumor suppressor protein in SCC...

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Share to Carcinoma, Squamous Cell
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to GTPase-Activating Proteins

Share to Matrix Metalloproteinase 2

Share to Matrix Metalloproteinase 9

Share to Neoplasm Invasiveness

Share to Oropharyngeal Neoplasms

Source

Identifiers

PMID: 18483282
DOI: 10.1158/0008-5472.CAN-07-2755

Genes

MMP2
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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