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Article

Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1.

The Journal of biological chemistry - 14 Nov 2003

Masumoto Kiyonari, Sakata Yasuhisa, Arima Kazuhiko, Nakao Isao, Izuhara Kenji

Abstract excerpt

The squamous cell carcinoma antigen (SCCA) 1 and its homologous molecule, SCCA2, belong to the ovalbumin-serpin family. Although SCCA2 inhibits serine proteinases such as cathepsin G and mast cell chymase, SCCA1 targets cysteine proteinases such as cathepsin S, K, L, and papain. SCCA1 is therefor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12949073
DOI: 10.1074/jbc.M307741200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12949073-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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