PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma

doi:10.1155/2009/963209

Article

PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma

1 Jan 2009

Abstract excerpt

The emergence of highly aggressive subtypes of human cutaneous squamous cell carcinoma (SCC) often reflects increased autocrine/paracrine TGF-beta synthesis and epidermal growth factor receptor (EGFR) amplification. Cooperative TGF-beta/EGFR signaling promotes cell migration and induces expression of both proteases and protease inhibitors that regulate stromal remodeling resulting in the acquisition of an...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.