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Article

Molecular cloning of seprase: a serine integral membrane protease from human melanoma

1 Jul 1997

Abstract excerpt

Seprase is a homodimeric 170 kDa integral membrane gelatinase whose expression correlates with the invasiveness of the human melanoma cell line LOX. Here, we report the molecular cloning of a cDNA that encodes the 97 kDa subunit of seprase. Its deduced amino acid sequence predicts a type II integral membrane protein with a cytoplasmic tail of 6 amino acids, followed by a transmembrane domain of 20 amino acids and...

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PMID: 9247085
DOI: 10.1016/s0925-4439(97)00032-x

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