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Article

The Respiratory Syncytial Virus Polymerase Has Multiple RNA Synthesis Activities at the Promoter

18 Oct 2012

Abstract excerpt

Respiratory syncytial virus (RSV) is an RNA virus in the Family Paramyxoviridae. Here, the activities performed by the RSV polymerase when it encounters the viral antigenomic promoter were examined. RSV RNA synthesis was reconstituted in vitro using recombinant, isolated polymerase and an RNA oligonucleotide template representing nucleotides 1-25 of the trailer complement (TrC) promoter. The RSV polymerase was...

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PMID: 23093940
DOI: 10.1371/journal.ppat.1002980

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