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Article

Inhibition of MHC Class I Is a Virulence Factor in Herpes Simplex Virus Infection of Mice

28 Sept 2005

Abstract excerpt

Herpes simplex virus (HSV) has a number of genes devoted to immune evasion. One such gene, ICP47, binds to the transporter associated with antigen presentation (TAP) 1/2 thereby preventing transport of viral peptides into the endoplasmic reticulum, loading of peptides onto nascent major histocompatibility complex (MHC) class I molecules, and presentation of peptides to CD8 T cells. However, ICP47 binds poorly to...

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Identifiers

PMID: 16201019
DOI: 10.1371/journal.ppat.0010007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of MHC Class I Is a Virulence Factor in Herpes Simplex Virus Infection of MicePMID 16201019Read ↗

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