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Murine cytomegalovirus degrades MHC class II to colonize the salivary glands

15 Feb 2018

Abstract excerpt

Cytomegaloviruses (CMVs) persistently and systemically infect the myeloid cells of immunocompetent hosts. Persistence implies immune evasion, and CMVs evade CD8+ T cells by inhibiting MHC class I-restricted antigen presentation. Myeloid cells can also interact with CD4+ T cells via MHC class II (MHC II). Human CMV (HCMV) attacks the MHC II presentation pathway in vitro, but what role this evasion might play in...

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PMID: 29447285
DOI: 10.1371/journal.ppat.1006905

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