Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of Major Histocompatibility Complex Class I Antigen Presentation in Pig and Primate Cells by Herpes Simplex Virus Type 1 and 2 ICP47

1 Jun 1998

Abstract excerpt

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) express an immediate-early protein, ICP47, that effectively inhibits the human transporter associated with antigen presentation (TAP), blocking major histocompatibility complex (MHC) class I antigen presentation to CD8+ T cells. Previous work indicated that the mouse TAP is relatively resistant to inhibition by the HSV-1 and HSV-2 ICP47 proteins (ICP47-1 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Herpesvirus Infections and Treatments
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9573278
DOI: 10.1128/jvi.72.6.5076-5084.1998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of Major Histocompatibility Complex Class I Antigen Presentation in Pig and Primate Cells by Herpes Simplex Virus Type 1 and 2 ICP47PMID 9573278Read ↗

Inhibition of MHC Class I Is a Virulence Factor in Herpes Simplex Virus Infection of MiceSemantic proximity Read ↗

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes.Semantic proximity Read ↗

The Active Site of ICP47, a Herpes Simplex Virus–encoded Inhibitor of the Major Histocompatibility Complex (MHC)-encoded Peptide Transporter Associated with Antigen Processing (TAP), Maps to the NH2-terminal 35 ResiduesSemantic proximity Read ↗

Cell lines transfected with the TAP inhibitor ICP47 allow testing peptide binding to a variety of HLA class I molecules.Semantic proximity Read ↗

Expression of Herpes Simplex Virus ICP47 and Human Cytomegalovirus US11 Prevents Recognition of Transgene Products by CD8 + Cytotoxic T LymphocytesSemantic proximity Read ↗

The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins.Semantic proximity Read ↗

Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex.Semantic proximity Read ↗

CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells.Semantic proximity Read ↗

Structure of the transporter associated with antigen processing trapped by herpes simplex virusSemantic proximity Read ↗

Impaired Transporter Associated with Antigen Processing-Dependent Peptide Transport during Productive EBV InfectionSemantic proximity Read ↗

Simplexviruses Successfully Adapt to Their Host by Fine-Tuning Immune ResponsesSemantic proximity Read ↗

Infection and inhibition of human cytotoxic T lymphocytes by herpes simplex virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.