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Article

Global regulation by the yeast Spt10 protein is mediated through chromatin structure and the histone upstream activating sequence elements.

Molecular and cellular biology - 1 Oct 2005

Eriksson Peter R, Mendiratta Geetu, McLaughlin Neil B, Wolfsberg Tyra G, Mariño-Ramírez Leonardo, Pompa Tiffany A, Jainerin Mohendra, Landsman David, Shen Chang-Hui, Clark David J

Abstract excerpt

The yeast SPT10 gene encodes a putative histone acetyltransferase (HAT) implicated as a global transcription regulator acting through basal promoters. Here we address the mechanism of this global regulation. Although microarray analysis confirmed that Spt10p is a global regulator, Spt10p was not detected at any of the most strongly affected genes in vivo. In contrast, the presence of Spt10p at the core histone...

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Identifiers

PMID: 16199888
DOI: 10.1128/MCB.25.20.9127-9137.2005
PMCID: PMC1265784

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Source receipt: pubmed, retrieved 7 Sept 2026.

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