Article
Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction.
Molecular and cellular biology - 1 Jan 1999
Sterner D E, Grant P A, Roberts S M, Duggan L J, Belotserkovskaya R, Pacella L A, Winston F, Workman J L, Berger S L
Abstract excerpt
SAGA, a recently described protein complex in Saccharomyces cerevisiae, is important for transcription in vivo and possesses histone acetylation function. Here we report both biochemical and genetic analyses of members of three classes of transcription regulatory factors contained within the SAGA complex. We demonstrate a correlation between the phenotypic severity of SAGA mutants and SAGA structural integrity....
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