Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Oct 1992

Jiang Y W, Stillman D J

Abstract excerpt

We have cloned and sequenced the SIN4 gene and determined that SIN4 is identical to TSF3, identified as a negative regulator of GAL1 gene transcription (S. Chen, R.W. West, Jr., S.L. Johnson, H. Gans, and J. Ma, submitted for publication). Yeast strains bearing a sin4 delta null mutation have been constructed and are temperature sensitive for growth and display defects in both negative and positive regulation of...

Topics

Amino Acid Sequence
Base Sequence
Chromatin
Cloning, Molecular
DNA, Fungal
Fungal Proteins
Genes, Fungal
Mediator Complex
Molecular Sequence Data
Mutagenesis
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Restriction Mapping

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 1406639
DOI: 10.1128/mcb.12.10.4503-4514.1992
PMCID: PMC360376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1406639-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae.PMID 1406639Read ↗

Activation of basal transcription by a mutation in SIN4, a yeast global repressor, occurs through a mechanism different from activator-mediated transcriptional enhancement.Semantic proximity Read ↗

Effects of Sin- versions of histone H4 on yeast chromatin structure and function.Semantic proximity Read ↗

Evidence that Spt2/Sin1, an HMG-like factor, plays roles in transcription elongation, chromatin structure, and genome stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

Analysis of transcriptional activation at a distance in Saccharomyces cerevisiae.Semantic proximity Read ↗

Gal11 is a general activator of basal transcription, whose activity is regulated by the general repressor Sin4 in yeast.Semantic proximity Read ↗

A negative regulator of HO transcription, SIN1 (SPT2), is a nonspecific DNA-binding protein related to HMG1.Semantic proximity Read ↗

Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription.Semantic proximity Read ↗

Genetic characterization of rbt mutants that enhance basal transcription from core promoters in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs.Semantic proximity Read ↗

Global regulation by the yeast Spt10 protein is mediated through chromatin structure and the histone upstream activating sequence elements.Semantic proximity Read ↗

Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding Sin3p binding proteins.Semantic proximity Read ↗

The Saccharomyces cerevisiae Cdc68 transcription activator is antagonized by San1, a protein implicated in transcriptional silencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.