Evidence that Spt6p controls chromatin structure by a direct interaction with histones.

doi:10.1126/science.272.5267.1473

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Article

Evidence that Spt6p controls chromatin structure by a direct interaction with histones.

Science (New York, N.Y.) - 7 Jun 1996

Bortvin A, Winston F

Abstract excerpt

Genetic analysis has implicated SPT6, an essential gene of Saccharomyces cerevisiae, in the control of chromatin structure. Mutations in SPT6 and particular mutations in histone genes are able to overcome transcriptional defects in strains lacking the Snf/Swi protein complex. Here it is shown tha...

Topics

Chromatin
DNA, Fungal
Fungal Proteins
Histone Chaperones
Histones
Humans
Mutation
Nuclear Proteins
Nucleosomes
Recombinant Fusion Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Transcription, Genetic
Transcriptional Elongation Factors

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