Article
The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.
Molecular and cellular biology - 1 May 2014
Saint Malika, Sawhney Sonal, Sinha Ishani, Singh Rana Pratap, Dahiya Rashmi, Thakur Anushikha, Siddharthan Rahul, Natarajan Krishnamurthy
Abstract excerpt
A common function of the TFIID and SAGA complexes, which are recruited by transcriptional activators, is to deliver TBP to promoters to stimulate transcription. Neither the relative contributions of the five shared TBP-associated factor (TAF) subunits in TFIID and SAGA nor the requirement for different domains in shared TAFs for transcriptional activation is well understood. In this study, we uncovered the...
Topics
- Arginase
- Basic-Leucine Zipper Transcription Factors
- Gene Expression Regulation, Fungal
- Mutation
- Promoter Regions, Genetic
- Protein Interaction Maps
- Protein Structure, Tertiary
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- TATA-Binding Protein Associated Factors
- Trans-Activators