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Article

Transcription elongation factors repress transcription initiation from cryptic sites.

Science (New York, N.Y.) - 22 Aug 2003

Kaplan Craig D, Laprade Lisa, Winston Fred

Abstract excerpt

Previous studies have suggested that transcription elongation results in changes in chromatin structure. Here we present studies of Saccharomyces cerevisiae Spt6, a conserved protein implicated in both transcription elongation and chromatin structure. Our results show that, surprisingly, an spt6 mutant permits aberrant transcription initiation from within coding regions. Furthermore, transcribed chromatin in the...

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PMID: 12934008
DOI: 10.1126/science.1087374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Transcription elongation factors repress transcription initiation from cryptic sites.PMID 12934008Read ↗

Chromatin-sensitive cryptic promoters encode alternative protein isoforms in yeastSemantic proximity Read ↗

Mutant versions of the S. cerevisiae transcription elongation factor Spt16 define regions of Spt16 that functionally interact with histone H3.Semantic proximity Read ↗

Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae.Semantic proximity Read ↗

Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription.Semantic proximity Read ↗

Control of chromatin structure by spt6: different consequences in coding and regulatory regions.Semantic proximity Read ↗

Interaction between transcription elongation factors and mRNA 3'-end formation at the Saccharomyces cerevisiae GAL10-GAL7 locus.Semantic proximity Read ↗

Evidence that Spt2/Sin1, an HMG-like factor, plays roles in transcription elongation, chromatin structure, and genome stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Rtt106 histone chaperone is functionally linked to transcription elongation and is involved in the regulation of spurious transcription from cryptic promoters in yeast.Semantic proximity Read ↗

A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.Semantic proximity Read ↗

Glc7/PP1 triggers Paf1 complex dissociation from RNA polymerase II to enable transcription termination.Semantic proximity Read ↗

Spt5's central KOW domains and the Pol II stalk collaborate to regulate chromatin and 3'-end processing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Evidence that the localization of the elongation factor Spt16 across transcribed genes is dependent upon histone H3 integrity in Saccharomyces cerevisiae.Semantic proximity Read ↗

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