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Article

Competitive regulation of modular allosteric aptazymes by a small molecule and oligonucleotide effector.

RNA (New York, N.Y.) - 1 Oct 2005

Najafi-Shoushtari S Hani, Famulok Michael

Abstract excerpt

The hairpin ribozyme can catalyze the cleavage of RNA substrates by employing its conformational flexibility. To form a catalytic complex, the two domains A and B of the hairpin-ribozyme complex must interact with one another in a folding step called docking. We have constructed hairpin ribozyme variants harboring an aptamer sequence that can be allosterically induced by flavin mononucleotide (FMN). Domains A and...

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Source

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Identifiers

PMID: 16199761
DOI: 10.1261/rna.2840805
PMCID: PMC1370835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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