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Article

Tertiary contacts control switching of the SAM-I riboswitch.

Nucleic acids research - 1 Mar 2011

Hennelly Scott P, Sanbonmatsu Karissa Y

Abstract excerpt

Riboswitches are non-coding RNAs that control gene expression by sensing small molecules through changes in secondary structure. While secondary structure and ligand interactions are thought to control switching, the exact mechanism of control is unknown. Using a novel two-piece assay that competes the anti-terminator against the aptamer, we directly monitor the process of switching. We find that the...

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Identifiers

PMID: 21097777
DOI: 10.1093/nar/gkq1096
PMCID: PMC3064774

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