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Article

ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory.

Neurobiology of disease - 1 Aug 2003

Levi Ofir, Jongen-Relo Ana L, Feldon Joram, Roses Allen D, Michaelson Daniel M

Abstract excerpt

Alzheimer's disease (AD) is associated with genetic risk factors, of which the allele E4 of apolipoprotein E (apoE4) is the most prevalent, and is affected by environmental factors that include education early in life and socioeconomic background. The extent to which environmental factors affect...

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Identifiers

PMID: 12901842
DOI: 10.1016/s0969-9961(03)00045-7

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12901842-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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