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Article

ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory.

Neurobiology of disease - 1 Aug 2003

Levi Ofir, Jongen-Relo Ana L, Feldon Joram, Roses Allen D, Michaelson Daniel M

Abstract excerpt

Alzheimer's disease (AD) is associated with genetic risk factors, of which the allele E4 of apolipoprotein E (apoE4) is the most prevalent, and is affected by environmental factors that include education early in life and socioeconomic background. The extent to which environmental factors affect the phenotypic expression of the AD genetic risk factors is not known. Here we show that the neuronal and cognitive...

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PMID: 12901842
DOI: 10.1016/s0969-9961(03)00045-7

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NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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