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Article

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 1999

Buttini M, Orth M, Bellosta S, Akeefe H, Pitas R E, Wyss-Coray T, Mucke L, Mahley R W

Abstract excerpt

Apolipoprotein (apo) E isoforms are key determinants of susceptibility to Alzheimer's disease. The apoE4 isoform is the major known genetic risk factor for this disease and is also associated with poor outcome after acute head trauma or stroke. To test the hypothesis that apoE3, but not apoE4, protects against age-related and excitotoxin-induced neurodegeneration, we analyzed apoE knockout (Apoe-/-) mice...

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Identifiers

PMID: 10366621
PMCID: PMC6782676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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